Figure 8.

Maraba MG1 virus enhances natural killer cell function via infection and activation of conventional dendritic cells to reduce postoperative metastatic disease. Maraba MG1 administration results in cDC infection and activation, which in turn activates NK cell cytotoxicity. Preoperative administration of the live or attenuated MG1 results in NK cell activation via cDC, thereby preventing surgery-induced dysfunction and removal of tumor cell emboli and micrometastases in the postoperative period.