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Analysis of the binding interface between r-D3E8 and hIL-6 on a modular basis. (a) Hydrogen bonds of Asn84 and Asn85 on module 1. (b) Electrostatic interaction of Glu128 on module 3. (c) Hydrophobic interactions of Phe177 and Tyr201 on modules 5 and 6. (d) Hydrogen bond of Tyr172 and charged interaction of Asp198 on modules 5 and 6. Structural details of the interaction sites are drawn as boxed regions. Selected interactions are shown in dashed lines.
