Figure 7.

Improved cross protection for over a year is supported by M2e5x VLP-supplemented vaccine. BALB/c mice (N = 4) were immunized with influenza split vaccine alone (Split) or influenza split vaccine supplemented with M2e5x VLPs (Split+M2e5x). Groups of mice were intranasally challenged with a lethal dose (5xLD₅₀) of influenza virus, A/Philippines/2/82 (H3N2), after 12 months of vaccination. (a) Average body weight changes. (b) Survival rates. Body weight and survival rates were monitored for 14 days. P value indicates significant difference between split+M2e5x and split vaccinated groups. Error bars indicate mean ± SEM. M2e, M2 ectodomain; VLP, virus-like particles.