Table 2.
Gene ontology analysis of CG-1521-resistant strains using DAVID bioinformatics
| Gene ontology analysis: resistant strains | ||||
|---|---|---|---|---|
| Category (GO-FAT) | p-value | Corrected p-value |
Represented strains | |
| tRNA Modification | GO:0006400 | 2.2E-4 | 1.1E-2 | 7 |
| tRNA Wobble Uridine Modification | GO:0002098 | 6.9E-7 | 3.2E-4 | 7 |
| Transcription | GO:0006350 | 1.1E-2 | 0.19 † | 15 |
| Regulation of Transcription, DNA-dependent | GO:0006355 | 2.9E-6 | 6.6E-4 | 20 |
| Negative Regulation of Transcription | GO:0045892 | 6.5E-5 | 5.9E-3 | 11 |
| Regulation of Transcription from RNA Pol II Promoter | GO:0006357 | 2.4E-5 | 2.7E-3 | 14 |
| Srb Mediator Complex | GO:0016592 | 1.1E-5 | 1.7E-3 | 6 |
Eighty resistant strains were identified in the yeast gene deletion library screen. Reported p values have been corrected using the methods described by Benjamini and Hochberg. The GO FAT database, developed as part of DAVID, removes very broad GO terms and comprises more specific terms [28, 29]. †Corrected p-values not significant.