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. Author manuscript; available in PMC: 2014 Jul 9.
Published in final edited form as: Photochem Photobiol Sci. 2011 Jul 20;11(1):163–172. doi: 10.1039/c1pp05131h

Fig. 2. Gene expression changes affecting the autophagic-lysosomal pathway in human skin fibroblasts induced by UVA exposure or pharmacological inhibition of cathepsin B.

Fig. 2

Fig. 2

(A) Scatter blot of differential gene expression in response to chronic UVA exposure (‘3 week’ regimen) or CA074Me treatment (1 μM, q.d., 4 consecutive days) versus mock treatment as analyzed using the RT2 Human Autophagy™ PCR Expression Array (as summarized in Table 1). Upper and lower lines represent the cut-off indicating two fold up- or down-regulated expression, respectively. Arrows mark genes displaying similar expression changes in response to both treatments. (B) Comparative analysis of autophagic-lysosomal- and heat shock-related gene expression changes induced by UVA-versus CA074Me-treatment from combined RT2 Human Autophagy™ and Stress and Toxicity PathwayFinder™ PCR Expression arrays (n=3, mean ± SD; only where applicable: * denotes statistically significant differences (p<0.05) between treated and untreated control; # denotes statistically significant differences (p<0.05) between UVA- and CA074Me-treated samples).