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. Author manuscript; available in PMC: 2014 Jul 9.
Published in final edited form as: Handb Exp Pharmacol. 2013;(217):127–155. doi: 10.1007/978-3-642-25950-0_6

Fig. 1.

Fig. 1

Rhythmicity of metabolic processes according to time of day. The clock coordinates appropriate metabolic responses with the light/dark cycle and enhances energetic efficiency through temporal separation of anabolic and catabolic reactions in peripheral tissues. Circadian misalignment, which occurs during sleep disruption, shift work, and dietary alterations, disrupts the integration of circadian and metabolic systems, leading to adverse metabolic health effects [Figure modified from Bass and Takahashi (2010)]