TABLE I.
Patient and Disease Characteristics According to RAS Mutational Status
| MDS | RAS-wild type | RAS-mutated | All patients |
|---|---|---|---|
| No. | 1,024 | 43 | 1,067 |
| Age, median | 68 | 66 | 68 |
| Range | 18–94 | 26–84 | 18–94 |
| Sex (No. [%]) | |||
| Male | 676 (66) | 27 (63) | 703 (66) |
| Female | 348 (34) | 16 (37) | 364 (34) |
| AML | 73 (7) | 4 (9) | 77 (7) |
| WBC (×109/L) | 3.3 | ||
| Median range | 3.2 0.3–72.2 | 6.8 0.7–66.4 | 0.3–72.2 |
| Hemoglobin (g/dL) | 9.8 | ||
| Median range | 9.8 3–17.5 | 9.4 6.3–13.2 | 3–17.5 |
| Platelets (×109/L) | 73 | ||
| Median range | 75 1–1,040 | 51 1–382 | 1–1,040 |
| Bilirubin | 0.6 | 0.6 | 0.6 |
| Creatinine | 1 | 1 | 1 |
| BM blasts (%) | 5 | 9 | 5 |
| FAB (No. [%]) | |||
| RCMD-R | 47 (5) | 0 | 47 (4) |
| RCMD | 165 (16) | 3 (7) | 168 (16) |
| RARS | 50 (5) | 0 | 50 (5) |
| RAEB-T | 87 (8) | 8 (19) | 95 (9) |
| RAEB | 453 (44) | 18 (42) | 471 (44) |
| RA | 123 (12) | 1 (2) | 124 (12) |
| MDS-U | 18 (2) | 0 | 18 (2) |
| CMML | 68 (7) | 12 (28) | 80 (7) |
| 5q- | 13 (1) | 1 (2) | 14 (1) |
| IPSS (No. [%]) | |||
| High | 142 (14) | 9 (21) | 151 (14) |
| Int-2 | 269 (26) | 13 (30) | 282 (26) |
| Int-1 | 389 (38) | 15 (35) | 404 (38) |
| Low | 201 (20) | 4 (9) | 205 (19) |
| UN | 23 (2) | 2 (5) | 25 (2) |
No.: number of patients, FAB: French American British, IPSS: international prognostic scoring system, UN: unknown.