Fig. 5.

Circulating B cell numbers during etanercept treatment. Circulating B cell numbers in treated rheumatoid arthritis (RA) (n = 82) (a), treated psoriatic arthritis (PsA) (n = 32) (b), disease-modifying anti-rheumatic drugs (DMARDs)-free RA (n = 26) (c) and DMARDs-free PsA patients (n = 19) (d) during etanercept treatment. Data registered in healthy controls (n = 45) are reported in each panel. Data are shown as box-plots, where each box represents the 25th–75th percentiles; lines inside the box represent the median. Whiskers represent the 95% confidence interval (CI). Statistical analyses in patients and controls were performed using the Mann–Whitney U-test, while Wilcoxon's signed-rank test was used to compare cell population pre- and post-treatment. *P < 0·05; **P < 0·01; ***P < 0·001.