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. 2014 Jun 9;177(1):295–309. doi: 10.1111/cei.12317

Table 2.

Correlation between T cell subset activation status, viral load and expression of DNA sensors.

Parameters Cell population

Viral load versus CD38 CD4+ naive CD4+ CM CD4+ EM CD4+ TD All CD4+
R2 0·002109 0·2908 0·4544 0·1355 0·3033
P (two-tailed) 0·8475 0·0141 0·0011 0·1103 0·0119
P < 0·05* n.s. * ** n.s. *
CD4 naive CD4 CM CD4 EM CD4 TD All CD4
R2 0·2567 0·2456 0·4985 0·2659 0·5961
P (two-tailed) 0·0226 0·0263 0·0005 0·0200 <0·0001
P < 0·05: * * * *** * ****
IFI16 versus CD38 CD4+ naive CD4+ CM CD4+ EM CD4+ TD All CD4+
R2 0·001206 0·2163 0·2571 0·1589 0·1689
P (two-tailed) 0·8844 0·0388 0·0225 0·0817 0·0719
P < 0·05* n.s. * * n.s. n.s.
CD4 naive CD4 CM CD4 EM CD4 TD All CD4
R2 0·06794 0·1953 0·03297 0·1323 0·1052
P (two-tailed) 0·2670 0·0511 0·4436 0·1149 0·1630
P < 0·05* n.s. n.s. n.s. n.s. n.s.
cGAS versus CD38 CD4+ naive CD4+ CM CD4+ EM CD4+ TH All CD4+
R2 0·007774 0·003754 3·322e-005 0·09034 0·01475
P (two-tailed) 0·7117 0·7975 0·9808 0·1979 0·6101
P < 0·05* n.s. n.s. n.s. n.s. n.s.
CD4 naive CD4 CM CD4 EM CD4 TH All CD4
R2 0·04726 0·006327 0·06905 0·09444 0·01170
P (two-tailed) 0·3572 0·7389 0·2630 0·1875 0·6499
P < 0·05* n.s. n.s. n.s. n.s. n.s.
CXCL10 versus CD38 CD4+ naive CD4+ CM CD4+ EM CD4+ TH All CD4+
R2 0·01232 0·001954 0·0004880 0·1271 0·01324
P (two-tailed) 0·6937 0·8757 0·9377 0·1922 0·6831
P < 0·05* n.s. n.s. n.s. n.s. n.s.
CD4 naive CD4 CM CD4 EM CD4 TH All CD4
R2 0·01057 0·1273 0·2321 0·1011 0·04397
P (two-tailed) 0·7153 0·1918 0·0690 0·2481 0·4532
P < 0·05* n.s. n.s. n.s. n.s. n.s.

Significant correlations are marked with *P < 0·05, **P < 0·01, ***P < 0·001, ****P < 0·0001. CM = central memory; EM = effector memory; n.s. = non-significant; TD = terminally differentiated; IFI16 = interferon-inducible protein 16; cGAS = cyclic guanosine monophosphate–adenosine monophosphate synthase; CXCL10 = C-X-C motif chemokine 10.