Table 2.
Regulatory T cell (Treg) genes that are predicted miR-199a-5p targets
| Gene name | Treg versus Thelp (stimulated) | Treg versus Thelp (resting) | Treg versus Thelp (stimulated) | Treg versus Thelp (resting) |
|---|---|---|---|---|
| ANK3 | −2·232 | −1·773 | 0·001 | 0·012 |
| ARHGEF12 | −1·950 | −1·534 | 0·010 | 0·096 |
| ACVR2A | −1·538 | −1·456 | 0·005 | 0·007 |
| GLIPR1 | −0·754 | −1·093 | 0·053 | 0·078 |
| ZNF215 | −1·094 | −0·766 | 0·017 | 0·069 |
| SRGAP3 | −0·626 | −0·764 | 0·049 | 0·067 |
| KLF12 | −0·669 | −0·724 | 0·021 | 0·079 |
| C1GALT1 | −1·036 | −0·683 | 0·013 | 0·096 |
| SOS2 | −0·568 | −0·546 | 0·015 | 0·034 |
| ZNF117 | −0·804 | −0·506 | 0·062 | 0·094 |
| GALC† | −0·682 | −0·443 | 0·010 | 0·070 |
Differentially expressed Treg cell genes that are down-regulated and are predicted targets of miR-199a-5p. The first two columns are log2 fold change, and the last two columns represent the respective false discovery rate (FDR)-adjusted P-value.
†
Galactosylceramidase (GALC) was predicted by miRanda only; all other genes were found in the three databases (Targetscan, MiRanda and MirWalk). Thelp = T helper cells.