Table 4.
Interacting quantitative trait loci (QTLs) for leucocytosis†
| Leucocytes | Locus 1‡ | Locus 2‡ | LOD total§ | LOD IX¶ | LOD 1†† | LOD 2†† |
|---|---|---|---|---|---|---|
| cDCs | D1MIT387 | D17MIT21 | 8·8 | 3·8 | 4·8 | 0·2 |
| D1MIT387 | Fas | 24·5 | 8·5 | 4·8 | 10·8 | |
| D1MIT15 | D17MIT21 | 9·4 | 3·5 | 5·6 | 0·2 | |
| D1MIT15 | Fas | 28·8 | 11·0 | 5·6 | 10·8 | |
| pDCs | D1MIT387 | Fas | 8·0 | 3·0 | 1·0 | 4·0 |
| D1MIT15 | D17MIT21 | 10·4 | 4·5 | 2·5 | 3·2 | |
| D1MIT15 | Fas | 11·2 | 4·4 | 2·5 | 4·0 | |
| Granulocytes | D1MIT387 | Fas | 20·7 | 4·0 | 3·4 | 13·5 |
| D1MIT15 | D17MIT21 | 13·9 | 4·7 | 4·8 | 4·2 | |
| D1MIT15 | Fas | 28·9 | 9·2 | 4·8 | 13·5 | |
| Macrophages/monocytes | D1MIT387 | D17MIT21 | 7·9 | 3·9 | 3·7 | 0·3 |
| D1MIT387 | Fas | 9·7 | 2·9 | 3·7 | 3·2 | |
| D1MIT15 | D17MIT21 | 12·1 | 6·7 | 4·9 | 0·3 | |
| D1MIT15 | Fas | 14·7 | 6·0 | 4·9 | 3·2 |
†
Summary of interacting QTLs for leucocytosis with suggestive to significant statistics calculated by 500 permunation tests with MapManager QTX.
‡
Interacting pairs of QTLs.
§
Combined likelihood of odds (LOD) for association.
¶
LOD for interaction.
††
LOD of main effects of loci 1 and 2. LOD = logarithm of odds; cDCs = conventional dendritic cells; pDCs = plasmacytoid DCs.