Table 2.

Crude and adjusted hazard ratios for post-transplant outcomes according to the duration of ESA hyporesponsiveness

ESA Hyporesponsiveness *	Allograft Failure		Allograft Loss		All-Cause Mortality
	Crude HR † (95%CI)	Adjusted ‡ HR † (95%CI)	Crude HR † (95%CI)	Adjusted ‡ HR † (95%CI)	Crude HR † (95%CI)	Adjusted ‡ HR † (95% CI)
3-months	1.39 (1.21, 1.59)	1.23 (1.10, 1.42)	1.44 (1.31, 1.58)	1.39 (1.25, 1.54)	1.52 (1.36, 1.69)	1.61 (1.43, 1.81)
6-months	1.65 (1.35, 2.03)	1.43 (1.15, 1.78)	1.60 (1.38, 1.86)	1.59 (1.36, 1.87)	1.61 (1.35, 1.91)	1.85 (1.55, 2.23)

Allograft failure, present if: a second transplant, or return to dialysis. Allograft loss, present if: a second transplant, or return to dialysis, or death with a functioning graft.

^*ESA hyporesponsiveness defined as hematocrit ≤33% and erythropoiesis stimulating agent dose ≥75K units/month.

^†Hazard ratios derived from Cox proportional hazards models comparing ESA hyporesponsiveness to appropriate ESA response. All hazard ratios were statistically significant with p-value <0.01.

^‡Adjusted for age, gender, weight, race/ethnicity, hemodialysis vintage, hemodialysis catheter, diabetes status, and donor type.