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Aminoimidazole carboxamide ribonucleotide decreases the levels of different cyclins in uveal melanoma cells. 92.1 (A), MEL 270 (B), and MEL 202 (C) uveal melanoma cells were treated with AICAR at a concentration of either 1 or 2 mM for 24 hours. Quantitative RT-PCR analysis showed decrease of cyclins A1 and D1 in all cell lines,cyclin D3 in MEL 270 and cyclins A2 and E2 in MEL 202–treated cells in comparison with control cells. Significance (*) is assigned at P < 0.05.
