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Antiproliferative effect of AICAR on uveal melanoma cells is mediated via inhibition of 4E-BP1 phosphorylation in 92.1 and Mel 270, but not in Mel 202 cells. Western blot analysis of P-4E-BP1 in 92.1, Mel 720, and Mel 202 cells treated with AICAR at a concentration of either 1 or 2 mM for 24 hours. Density values of the bands are graphically expressed relative to control. Multiple bands represent separate biological samples. Significance (*) is assigned at P < 0.05.
