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. 2014 May 16;124(6):2750–2761. doi: 10.1172/JCI74604

Figure 1. Metabolomic screening reveals that blood S1P levels and erythrocyte SPHK1 activity are elevated in SCD Tg mice.

Figure 1

(A) Z-score quantification of lipids detected in the blood of both WT and SCD Tg mice. Among all lipids detected, S1P was one of the most substantially elevated in the blood of SCD Tg mice compared with that in WT mice (n = 6). (B and C) LC/MS POS platform measurement indicates that S1P levels in the (B) erythrocytes and (C) plasma of SCD mice were significantly elevated compared with those in WT mice (n = 6–8). (D) Total erythrocyte SPHK1 activity was significantly elevated in SCD Tg mice compared with that in WT mice (n = 8). (E) SPHK1 activities in purified reticulocytes and mature erythrocytes of SCD Tg mice. Values shown represent the mean ± SEM (n = 6–8). *P < 0.05 versus WT.