Figure 1.

Crystal structure of the four most N-terminal domains of ICAM-5. (a) Ribbon diagram of the monoclinic P2₁ structure with IgSF domains in blue (D1), cyan (D2), orange (D3) and red (D4). Two views are shown rotated by 90°. Side chains of asparagines in N-linked glycosylation sites are shown as sticks, and linked carbohydrates with a defined structure are depicted as spheres with carbon in yellow, nitrogen in blue and oxygen in red. Cysteines and disulfide bridges are shown in green. The β-strands, N-terminus and C-terminus are labelled. (b) Close-up views of the D1–D2, D2–D3 and D3–D4 interdomain junctions. Residues at the interdomain interface are shown as stick diagrams with oxygen in red and nitrogen in blue. Hydrophilic interactions are shown as dashed lines.