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. Author manuscript; available in PMC: 2014 Jul 9.
Published in final edited form as: J Nucl Med. 2014 Feb 13;55(3):500–507. doi: 10.2967/jnumed.113.121905

FIGURE 3.

FIGURE 3

Internalization of 125I-MORAb-004 by MS1-TEM1/fLuc cells with respect to the total amount of mAb bound per cell following incubation at 37°C as a function of dose (A) and time (B-C). Internalization was measured in presence or absence of an excess of unlabeled MORAb-004 (100 nM) in incubation medium to block hTEM1 surface protein binding. (C) Internalized fraction of 125I-MORAb-004 over time as a function of total cell-associated radioactivity. Values shown are mean of three independent experiments performed in quadruplicate. ***, P-value < 0.001.