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. Author manuscript; available in PMC: 2014 Jul 9.
Published in final edited form as: Cell Metab. 2013 Jul 2;18(1):106–117. doi: 10.1016/j.cmet.2013.04.021

Figure 2. LOKO livers are rescued from hepatic steatosis.

Figure 2

(A) Markers of hepatocellular necrosis (AST, ALT) were measured by colorimetric assay in WT, DKO, OB, and LOKO mice (N = 6-8 mice per group). (B) LOKO livers are smaller and lack significant steatosis by gross examination. (C) Representative H&E sections from OB and LOKO mice are shown. Magnification = 100×. (D) Hepatic lipids were extracted and quantified from WT, DKO, OB, and LOKO mice (N = 5-6 mice per group). (E) Hepatic gene expression was measured in WT, DKO, OB, and LOKO mice (N = 5-9 mice per group) at 24 weeks of age. Results are normalized first to expression of the housekeeping gene 36B4 and shown as fold induction over WT animals. Values are means +/− SEM. Statistical analysis by 1-way ANOVA with Bonferroni post-tests: *, P < 0.05; **, P < 0.01; ***, P < 0.001, N.S. not significant.