Table 27. Definitions of response to therapy in LN.

Complete response: Return of SCr to previous baseline, plus a decline in the uPCR to <500 mg/g (<50 mg/mmol).

Partial response: Stabilization (±25%), or improvement of SCr, but not to normal, plus a ⩾50% decrease in uPCR. If there was nephrotic-range proteinuria (uPCR ⩾3000 mg/g [⩾300 mg/mmol]), improvement requires a ⩾50% reduction in uPCR, and a uPCR <3000 mg/g [<300 mg/mmol].

Deterioration: There is no definition of deterioration in LN to define treatment failure that has been tested prospectively as an indication to change in initial therapy. A sustained 25% increase in SCr is widely used but has not been validated.