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. 2012 Dec 28;3(1):19–62. doi: 10.1038/kisup.2012.64

Figure 13.

Figure 13

Meta-analysis of NRI for all-cause mortality, CVD mortality, and ESRD. NRI summarizes the risk of clinical outcomes among participants who are reclassified from one estimated GFR category using the MDRD Study equation to another estimated GFR category using the CKD-EPI equation compared with those who are not reclassified. NRI greater than zero favors the CKD-EPI equation. NRI less than zero favors the MDRD Study equation. The sizes of the data markers are proportional to the inverse of the variance of the NRIs. CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; CVD, cardiovascular disease; ESRD, end-stage renal disease; GFR, glomerular filtration rate; MDRD, Modification of Diet in Renal Disease; NRI, net reclassification improvements. Reprinted with permission from Matsushita K, Mahmoodi BK, Woodward M, et al.107 Comparison of risk prediction using the CKD-EPI equation and the MDRD Study equation for estimated glomerular filtration rate. JAMA 2012; 307(18): 1941-1951. Copyright © (2012) American Medical Association. All rights reserved.