Table 1. Clinical, biochemical, and histological parameters of Nx rats and the controls, which received BMmSCs or hAFSCs.
Blood pressure (mm Hg) | Urinary protein (mg/24 h) | Serum creatinine (mg/dl) | Glomerulosclerosis index (%) | |
---|---|---|---|---|
Sham | 123±3 | 10.9±1 | 0.46±0.03 | 0.3±0.3 |
Sham+BMmSCs | 132±4 | 7.7±1 | 0.27±0.05 | 1.9±1.1 |
Sham+hAFSCs | 119±6 | 9.8±2 | 0.54±0.03 | 3.6±2.7 |
Nx | 185±4a,b,c | 92.9±14a,b,c | 1.05±0.15a,b,c | 26.3±5.5a,b,c |
Nx+BMmSCs | 162±7a,b,c,d | 31.9±6f | 0.62±0.09d | 5.4±2.4e |
Nx+hAFSCs | 152±5a,c,f | 39.5±12e | 0.74±0.08c | 5.2±4.5e |
Abbreviations: BMmSCs, bone marrow mesenchymal stem cells; hAFSCs, human amniotic fluid stem cells; Nx, 5/6 nephrectomy model.
Data are presented as mean±s.e.m.
aP<0.01 versus sham.
bP<0.01 versus sham+BMmSCs.
cP<0.05 versus sham+hAFSCs.
dP<0.05 versus Nx.
eP<0.01 versus Nx.
fP<0.001 versus Nx.