Figure 5.

Differential mRNA distribution of 7 proteins implicated in the protein ubiquitination pathway. Forebrain development is accompanied by a clear decrease in the mRNA expression of proteolysis-related proteins, ie, psma1, 4, 7, psmb1, 2, 4, and uba1, from P10 to P30 and Ad. Corresponding oligonucleotide sequences and Swiss-Prot entries can be found in Supplemental Table 1. Subcortical structures correspond to those indicated in Figure 4. S and I indicate supra- and infragranular layers of the neocortex, respectively, and highlight the switch in relative intensity with age. Scale bar = 2 mm.