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. Author manuscript; available in PMC: 2014 Jul 9.
Published in final edited form as: J Nat Prod. 2012 Feb 16;75(4):591–598. doi: 10.1021/np200823p

Figure 6.

Figure 6

Bryonolic acid (BA) (1) induces HO-1 in primary peritoneal macrophage and liver and is dependent on the Nrf2 pathway. (A) Primary peritoneal macrophages harvested from Nrf2 wild-type or Nrf2 knockout (C57BL6/J background) mice were treated with varying concentration of BA (1) for 48 hours. Immunoblot analysis of HO-1 protein levels in BA (1) treated primary macrophages. (B) immunoblot analysis of HO-1 protein levels in liver tissues of Nrf2 wild-type (upper panel) or Nrf2 knockout (lower panel) mice were treated with 500 mg/kg BA or vehicle for 8 hours by i.p.