Table 2.
Miceb | Flt3+hi MPPc | ALP | BLP | Pro B | Naïve Bd | Mature Bd |
---|---|---|---|---|---|---|
WT GFP | 14.1 ± 3.2 | 58.1 ± 7.0 | 83.0 ± 3.5 | 94.0 ± 0.5 | 83.7 ± 0.5 | 16.3 ± 0.5 |
flt3l−/− GFP | 2.2 ± 0.4 | 20.1 ± 0.6 | 40.2 ± 2.7 | 81.8 ± 0.9 | 61.9 ± 4.6 | 38.2 ± 4.6 |
bcl2tg GFP | 7.8 ± 2.8 | 40.4 ± 4.2 | 81.6 ± 5.2 | 94.8 ± 3.5 | 73.8 ± 2.0 | 26.2 ± 2.0 |
bcl2tg flt3l−/− GFP | 1.7 ± 0.8 | 18.5 ± 0.3 | 38.6 ± 10.0 | 92.7 ± 1.8 | 62.7 ± 6.6 | 37.4 ± 6.6 |
Frequencies reflect mean ± SEM of two independent experiments.
n = 2 mice per genotype.
Flt3+hi multipotential progenitor defined as LSK+Flt3+hi.
Naive B cells are CD19+IgM+GFP+ whereas mature B cells are CD19+IgM+GFP−.