Table 1.
Frequency of substitutions at codon 138 in HIV-1 RT in isolates from RTI-naïve and -experienced individuals.
| Stanford HIV Database | BC Centre Database | WHO TDR Surveys | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Subtype B | Subtype C | p-valuea | Subtype B | Subtype C | p-valuea | Subtype B | Subtype C | p-valuea | |
| Treatment-naïve | |||||||||
| 138A | 350/17481 (2.0 %) | 415/6795 (6.1 %) | < 0.01 | 76/3320 (2.3 %) | 6/101 (5.9 %) | 0.03 | 0/132 (0%) | 97/1296 (7.5%) | < 0.01 |
| 138G | 35/17481 (0.2 %) | 20/6795 (0.3 %) | 0.18 | 3/3320 (0.09 %) | 1/101 (1 %) | 0.12 | 0/132 (0%) | 3/1296 (0.23%) | 0.58 |
| 138K | 17/17481 (0.1 %) | 13/6795 (0.2 %) | 0.07 | 1/3320 (0.03 %) | 1/101 (1 %) | 0.06 | 0/132 (0%) | 2/1296 (0.15%) | 0.65 |
| 138Q | 0/17481 (0.0 %) | 0/6795 (0 %) | N/A | 0/3320 (0 %) | 0/101 (0 %) | N/A | 0/132 (0%) | 2/1296 (0.15%) | 0.65 |
| RTI-experienced | |||||||||
| 138A | 402/20112 (2.0 %) | 210/3439 (6.1 %) | < 0.01 | 168/6593 (2.5 %) | 13/222 (5.9 %) | < 0.01 | |||
| 138G | 80/20112 (0.4 %) | 14/3439 (0.4 %) | 0.88 | 9/6593 (0.1 %) | 0/222 (0.0 %) | 1.0 | |||
| 138K | 60/20112 (0.3 %) | 34/3439 (1.0 %) | < 0.01 | 14/6593 (0.2 %) | 2/222 (0.9 %) | 0.09 | |||
| 138Q | 121/20112 (0.6 %) | 38/3439 (1.1 %) | < 0.01 | 7/6593 (0.1 %) | 0/222 (0.0 %) | 1.0 | |||
| NRTI- but not NNRTI-experienced | |||||||||
| 138A | 83/3966 (2.1 %) | 24/288 (8.4 %) | < 0.01 | 118/4521 (2.6 %) | 6/120 (5 %) | 0.14 | |||
| 138G | 4/3966 (0.1 %) | 2/288 (0.7 %) | 0.08 | 7/4521 (0.2 %) | 0/120 (0.0 %) | 1.0 | |||
| 138K | 8/3966 (0.2 %) | 3/288 (1.1 %) | 0.04 | 9/4521 (0.2 %) | 1/120 (0.8 %) | 0.23 | |||
| 138Q | 4/3966 (0.1 %) | 0/288 (0 %) | 0.59 | 6/4521 (0.1 %) | 0/120 (0.0 %) | 1.0 | |||
| NRTI- and NNRTI-experienced | |||||||||
| 138A | 113/6297 (1.8 %) | 112/1927 (5.8 %) | < 0.01 | 50/2069 (2.4%) | 7/102 (6.9%) | 0.02 | |||
| 138G | 38/6297 (0.6 %) | 6/1927 (0.3 %) | 0.18 | 2/2069 (0.1%) | 0/102 (0.0%) | 1.0 | |||
| 138K | 19/6297 (0.3 %) | 12/1927 (0.6 %) | 0.07 | 5/2069 (0.2%) | 1/102 (1%) | 0.25 | |||
| 138Q | 57/6297 (0.9 %) | 17/1927 (0.9 %) | 0.93 | 1/2069 (0.0%) | 0/102 (0.0%) | 1.0 | |||
a
Statistical analyses of the prevalence of mutations at codon 138 in sequences from individuals infected with subtype B versus those infected with subtype C virus were performed using a Chi-square test.