Table 2. Logistic regression analyses of associations between hTERT rs2736098 G>A and TERT-CLPTM1L rs401681 C>T polymorphisms and risk of ESCC.
| Cases (n = 629) | Controls (n = 686) | ||||||||
| Genotype | n | (%) | n | (%) | Crude OR (95%CI) | P | Adjusted OR a (95%CI) | P | |
| hTERT rs2736098 G>A | |||||||||
| GG | 245 | (40.83) | 270 | (41.47) | 1.00 (reference value) | 1.00 (reference value) | |||
| GA | 277 | (46.17) | 306 | (47.00) | 1.00 (0.79–1.27) | 0.984 | 1.01 (0.79–1.28) | 0.970 | |
| AA | 78 | (13.00) | 75 | (11.52) | 1.15 (0.80–1.65) | 0.459 | 1.18 (0.82–1.71) | 0.372 | |
| AA vs. GA vs. GG | 0.727 | ||||||||
| GA/AA | 355 | (59.17) | 381 | (58.53) | 1.03 (0.82–1.29) | 0.818 | 1.04 (0.83–1.31) | 0.742 | |
| GG/GA | 522 | (87.00) | 576 | (88.48) | 1.00 (reference value) | 1.00 (reference value) | |||
| AA | 78 | (13.00) | 75 | (11.52) | 1.15 (0.82–1.61) | 0.425 | 1.18 (0.84–1.67) | 0.348 | |
| G allele | 767 | (63.92) | 846 | (64.98) | 1.00 (reference value) | — | |||
| A allele | 433 | (36.08) | 456 | (35.02) | 1.05 (0.89–1.23) | 0.580 | — | — | |
| TERT-CLPTM1L rs401681 C>T | |||||||||
| CC | 288 | (47.68) | 266 | (40.06) | 1.00 (reference value) | 1.00 (reference value) | |||
| CT | 252 | (41.72) | 317 | (47.74) | 0.73 (0.58–0.93) | 0.010 | 0.74 (0.58–0.94) | 0.012 | |
| TT | 64 | (10.60) | 81 | (12.20) | 0.73 (0.51–1.05) | 0.093 | 0.75 (0.51–1.09) | 0.126 | |
| TT vs. CT vs. CC | 0.024 | ||||||||
| CT/TT | 316 | (52.32) | 398 | (59.94) | 0.73 (0.59–0.92) | 0.006 | 0.74 (0.59–0.93) | 0.009 | |
| CC/CT | 540 | (89.40) | 583 | (87.80) | 1.00 (reference value) | 1.00 (reference value) | |||
| TT | 64 | (10.60) | 81 | (12.20) | 0.85 (0.60–1.21) | 0.371 | 0.87 (0.61–1.24) | 0.447 | |
| C allele | 828 | (68.54) | 849 | (63.93) | 1.00 (reference value) | — | |||
| T allele | 380 | (31.46) | 479 | (36.07) | 0.81 (0.69–0.96) | 0.014 | — | — | |
a
Adjusted for age, sex, smoking and drinking status; Bold values are statistically significant (P<0.05).