Table 2. CpG Sites Selected From the Initial and the Second EWAS Panel.
| Gene | CpG site | Methylation level (%) | p | ||
|---|---|---|---|---|---|
|
| |||||
| Cases | Controls | Difference | |||
| Initial panela | N = 7 | N = 7 | |||
| LEPR | cg21655790 | 18.6 | 12.6 | 6.0 | .002 |
| SNRPN | cg26033681 | 44.3 | 49.4 | -5.1 | .009 |
| KREMEN1 | cg01791232 | 23.7 | 18.1 | 5.6 | .009 |
| LY86 | cg02212836 | 51.5 | 43.0 | 8.5 | .009 |
| Second panela | N = 48 | N = 48 | |||
| LEPR* | cg21655790 | — | — | — | — |
| SNRPN | cg26033681 | 53.9 | 52.9 | 1.0 | .169 |
| KREMEN1 | cg01791232 | 25.0 | 23.9 | 1.1 | .028 |
| LY86 | cg02212836 | 58.4 | 54.7 | 3.7 | .008 |
Note:
a
Adjusted for age in the initial panel and adjusted for age and gender in the second panel;
*
Not included in the 450K chip.