. Author manuscript; available in PMC: 2014 Jul 9.

Published in final edited form as: Twin Res Hum Genet. 2014 Apr 15;17(3):183–191. doi: 10.1017/thg.2014.22

Table 3. DNA Methylation of LY86 and Obesity in the Replication Panels.

Gene	CpG site	Methylation level (%)			p	p (adjusted)^a	p (meta)^b

		Cases	Controls	Difference
Replication panel 1		N = 46	N = 46
LY86	LY86_1	41.8	38.1	3.7	.03	.08	—
	LY86_2	44.2	39.0	5.2	<.001	.005	—
	LY86_3	24.6	20.8	3.8	.001	.009	—
	LY86_4	56.1	51.5	4.6	.008	.05	—
	LY86_5^*	56.7	52.2	4.5	.009	.05	—
	LY86_6	51.4	46.8	4.6	.003	.03	—
Replication panel 2		N = 230	N = 413
LY86	LY86_1	44.3	42.4	1.9	.002	.01	.003
	LY86_2	46.3	44.6	1.7	.002	.01	<.001
	LY86_3	24.8	23.5	1.3	.003	.02	.001
	LY86_4	49.3	47.0	2.3	.001	.01	.002
	LY86_5^*	49.7	47.7	2.0	.006	.03	.007
	LY86_6	51.9	49.7	2.2	.001	.02	.004

Note:

LY86_5 is the targeted CpG site cg02212836;

Adjusted for age in the replication panel 1 and adjusted for age, gender, and race in the replication panel 2;

Meta analysis on the replication panels 1 (age-adjusted) and 2 (age-, gender- and race-adjusted).