Table 4. Associations of Methylation Levels of the LY86 Gene With Body Mass Index and Additional Indices for Adiposity in the Third Panel (N = 703) Representing the General Population of Youth.
CpG sitesa | BMI | % body fat | VATb | SAATb | ||||
---|---|---|---|---|---|---|---|---|
|
|
|
|
|||||
Partial correlationc | p | Partial correlationc | p | Partial correlationc | p | Partial correlationc | p | |
LY86_1 | .131 | <.001 | .138 | <.001 | .147 | .002 | .130 | .006 |
LY86_2 | .100 | .008 | .097 | .01 | .151 | .001 | .137 | .004 |
LY86_3 | .089 | .02 | .090 | .02 | .120 | .01 | .105 | .03 |
LY86_4 | .094 | .01 | .087 | .02 | .126 | .008 | .094 | .05 |
LY86_5 | .088 | .02 | .093 | .01 | .137 | .004 | .097 | .04 |
LY86_6 | .067 | .08 | .077 | .04 | .127 | .008 | .085 | .08 |
LY86_pc1d | .096 | .01 | .099 | .009 | .138 | .004 | .109 | .02 |
Note: BMI = body mass index; VAT = visceral adipose tissue; SAAT = subcutaneous abdominal adipose tissue;
Adjusted for batch;
Log-transformed;
Adjusted for age, gender, and race;
The first principal component score calculated based on the methylation levels of six CpG sites, adjusted for batch.