Table 1.
Clinicopathologic features of sporadic and probable Lynch Syndrome-associated endometrial cancers.
| Clinical Features | Sporadic EC1 N (%) |
PLS EC2 N (%) |
p -value |
|---|---|---|---|
|
| |||
| Median Age at Diagnosis (yrs) Range |
61 (18–92) | 61 (42–87) | |
|
| |||
| Age (yrs) | |||
| < 50 | 52 (14.2) | 10 (23.3) | 0.12 |
| ≥ 50 | 313 (85.8) | 33 (76.7) | |
|
| |||
| BMI (kg/m2) | |||
| < 30 | 121 (33.2) | 17 (39.5) | 0.41 |
| ≥ 30 | 243 (66.8) | 26 (60.5) | |
|
| |||
| History of Diabetes | |||
| Y | 89 (24.4) | 9 (20.9) | 0.62 |
| N | 276 (75.6) | 34 (79.1) | |
|
| |||
| History of Hypertension | |||
| Y | 201 (55.1) | 18 (41.9) | 0.10 |
| N | 164 (44.9) | 25 (58.1) | |
|
| |||
| 3 Family History of EC | |||
| Y | 35 (9.8) | 4 (9.8) | > 0.99 |
| N | 323 (90.2) | 37 (90.2) | |
|
| |||
| 3 Family History of CRC4 | |||
| Y | 58 (16.2) | 8 (19.0) | 0.63 |
| N | 301 (83.8) | 34 (81.) | |
|
| |||
| Family History of CRC or EC | |||
| Y | 87 (24.2) | 12 (28.6) | 0.54 |
| N | 272 (75.8) | 30 (71.4) | |
| Pathologic Features | Sporadic EC N (%) |
PLS EC N (%) |
p -value |
|---|---|---|---|
|
| |||
| Histology | |||
| Endometrioid | 299 (81.9) | 37 (86.0) | 0.67 |
| Non-endometrioid | 66 (18.1) | 6 (14.0) | |
|
| |||
| FIGO5 Stage | |||
| I & II | 289 (79.2) | 37 (86.0) | 0.42 |
| III & IV | 76 (20.8) | 6 (14.0) | |
|
| |||
| FIGO Grade | |||
| 1 & 2 | 267 (73.2) | 32 (74.4) | 0.86 |
| 3 | 98 (26.8) | 11 (25.6) | |
|
| |||
| Depth of myometrial invasion | |||
| < 50% | 257 (70.4) | 32 (74.4) | 0.58 |
| ≥ 50% | 108 (29.6) | 11 (25.6) | |
|
| |||
| Tumor Location | |||
| Corpus | 357 (97.8) | 38 (88.4) | 0.007 |
| Lower uterine segment | 8 (2.2) | 5 (11.6) | |
|
| |||
| Largest gross tumor dimension (cm) | |||
| Mean ± Standard Deviation | 4.3 ± 3.2 | 3.6 ± 2.9 | 0.13 |
| Median (range)6 | 4 (0–25) | 3.5 (0–13) | |
1
EC; Endometrial Cancer
2
PLS EC; Probable Lynch Syndrome-associated endometrial cancer
3
Family history of EC or CRC; patient has a first- or second-degree relative with a diagnosis of endometrial cancer or colorectal cancer
4
CRC; Colorectal cancer
5
FIGO; International Federation of Gynecology and Obstetrics
6
Some tumors were not apparent grossly, but were identified by microscopic examination of the entire endometrium. These tumors were designated with a largest gross tumor dimension of 0.