Table 1.

Diazomethane (DM)

Initial costs ($)			Reaction Costs ($)
Equipment	Cost($)	Item	Cost($)/unit	Quantity	Cost($)
Stirrer	726.60	Labor	30.00/h	0.15h	4.50
Stirrer bar	3.54	KOH	0.04/g	0.05 g	0.01
Flask	42.90	EtOH	0.01/ml	0.09ml	0.01
Funnel	120.00	Ether	0.01 /ml	0.50ml	0.01
Total	1186.54	Diazald	0.64 Ig	0.05 g	0.03
		Tube	1/reaction	1 tube	1.00
		Screwcap	1/reaction	1 cap	1.00
Labor / (100 samples)	90.00	Isopropanol	0.05/ml	0.45ml	0.02
Mini diazald	293.50	Dryice	0.80g	1g	0.80
total	383.50	Nitrogen	160/2000 psi	2 psi	0.16
Total	1570.04	Total			7.54

Trimethylsilyldiazomethane (TMS DM)
Initial costs ($)			Reaction Costs ($)
Equipment	Cost($)	Item	Cost($) /unit	Quantity	Cost($)
Stirrer	726.60	Labor	30.00/h	0.20h	6.00
Stirrer bar	3.54	DIPEA	O.55/g	0.08g	0.04
Total	730.14	Ether	0.01 /ml	2.00ml	0.03
		MqSO2	0.10/g	1.00 g	0.10
		MeCN	0 05/ml	0.90ml	0.05
		MeOH	0 05/ml	0.10ml	0.00
		Tube	1/reaction	1 tube	1.00
		Screwcop	1/reaction	1 cap	1.00
		TMS-DM	2.45/ml	0.10ml	0.25
Total	730.14	Total			8.47

Cost ($) / sample volume	TMS-DM	DM
100 samples	1,577.14	2,324.04
1,000 samples	9,200.14	12,S61.S4
10,000 samples	85,430.14	114,936.S4