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. Author manuscript; available in PMC: 2014 Jul 9.
Published in final edited form as: Circ J. 2012 Jul 30;76(8):1811–1818. doi: 10.1253/circj.cj-12-0801

Figure 2.

Figure 2

Mac-1 signaling, monocyte differentiation and pro-inflammatory gene expression. Mac-1 engagement and clustering recruits a Toll/IL-1 receptor family-like cascade involving IRAK1 (IL-1 receptor-associated kinase), TRAF-6 (TNF- receptor-associated factor 6) and TAK-1 (TGF-β-activated kinase) to modulate NFκB activity. Clustering of Mac-1 also leads to downregulation of Foxp1, which functions as a transcriptional repressor of the MCSF-1 (macrophage colony-stimulating factor) receptor, c-fms. Leukocyte integrin signaling pathways converge on spleen tyrosine kinase (Syk), a 72-kDa signaling protein with kinase and scaffolding activities.