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. Author manuscript; available in PMC: 2014 Jul 9.
Published in final edited form as: Biochem J. 2011 Feb 15;434(1):83–92. doi: 10.1042/BJ20101358

Figure 9. hOsa2 represses c-myc and activates p21 gene transcription.

Figure 9

The transcriptional regulatory region of the c-myc and the p21 gene before and after the induction of hOsa2. In uninduced cells, the p21 promoter region is bound by c-Myc, which represses activation by Miz-1. Increased expression of hOsa2 represses c-myc gene expression, permitting Miz-1 to activate the p21 gene. hOsa2 also binds to the upstream regulatory region of the p21 gene and increases promoter activity through a p53-independent mechanism.