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. 2014 Jul 9;9(7):e101690. doi: 10.1371/journal.pone.0101690

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© 2014 Mishra et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) In the dynamical model, the population is divided into four different activity classes based on the frequency of yearly partner change (FSWs/clients, two multiple partnership classes, and a low-activity class). Four partnership types are possible: commercial (regular or occasional), casual, or main. In the dynamical model, males and females who engage in higher-risk activity (commercial or casual sex) cease higher-risk activity and enter into the low-activity population reflecting a turn-over in each of the higher-risk activity groups (solid black lines). Multiple concurrent exposures are possible, and subpopulations are linked via bridging groups (individuals with multiple exposures). The partnerships are therefore shown with double-headed arrows to represent bridging between groups. (B) The complex Modes of Transmission model (cMOT) divides the population into the same activity classes as the dynamical model. The cMOT allows for multiple exposures to HIV (i.e. multiple types of partnerships). For visibility, only partnerships where infections are acquired by males are shown. Infections acquired by males and by females are counted separately, and partnerships are therefore shown with single-arrows to represent the lack of bridging between groups. Secondary infections and movement between risk-groups are not possible. (C) The generic Modes of Transmission model (gMOT) uses a simplified sexual structure, and only partnerships where infections are acquired by males are shown. In the gMOT, only one type of HIV exposure or partnership is possible, and subgroups are amalgamated in keeping with the generic MOT template [8], [9]. Infections acquired by males and by females are counted separately. As with the cMOT, single-headed arrows are used to represent different partnerships without bridging between groups. Hence, indirect transmission via bridging populations and secondary infections, and movement between risk-groups are not possible. MOT (modes of transmission); FSWs (female sex workers).