Table 4. Summary of SNPs in adjusted analysis for all tuberculosis patients.
| rs number | Alleles (Minor, major) | Minor allele % among controls | Major allele % among controls | Minor allele % among TB patients | Major allele % among TB patients | p-value * | Potential effect on proteina | |
| rs10208770 | G | T | 11% | 89% | 14.5% | 85.5% | 0.013 | No effect |
| rs10498244 | C | T | 14.6% | 85.4% | 18.7% | 81.3% | 0.007 | No effect |
| rs1135791 | C | T | 16.9% | 83.1% | 19.8% | 80.2% | 0.06 | Amino acid change M>T. Splice site changes. Possible downstream effect on bromo domain, Zn finger, SAND domain and nuclear localisation signal. |
| rs11678451 | C | T | 14.6% | 85.4% | 18% | 82% | 0.025 | No effect |
| rs16826860 | A | G | 30.2% | 69.8% | 33.9% | 66.1% | 0.051 | No effect |
| rs3948464 | T | C | 0.7% | 99.3% | 0.1% | 99.9% | 0.015 | L>S. Splice site changes. |
| rs7601176 | A | G | 11.4% | 88.6% | 8.7% | 91.3% | 0.03 | No effect |
| rs1427294 | C | T | 0.7% | 99.3% | 0.2% | 99.8% | 0.052 | No effect. |
SNP: Single nucleotide polymorphism. Rs number = Reference Single Nucleotide Polymorphism number.
a
Predicted functional effect on protein synthesis.
*P-value for unadjusted allelic association between all TB patients and control subjects calculated using Fisher’s exact test. M = Methionine, T = Threonine, S = serine, L = leucine.