Figure 3. Developing AHBA gene co-expression network and correlation matrix for known and prioritized Epileptic Encephalopathy genes.

Gene co-expression networks for the known Epileptic Encephalopathy genes in the top 5% of overall connections of the developing AHBA along with the 10 prioritized candidate Epileptic Encephalopathy genes (shown in blue) as determined by the connectivity measures that are estimated to have an eFDR = 0.25 (thresholded r) using qgraph (A) or represented as an ordered sample correlation (all r values) matrix (B) with ordering based on angular distance. See Figures S2 and S3 for adult AHBA and Celsius results respectively.