Skip to main content
. 2014 Jul 9;9(7):e101925. doi: 10.1371/journal.pone.0101925

Figure 3. Lung permeability evaluation in the i.p. or i.n. LPS-induced ALI model by FITC-Albumin and FITC-Dextran assay.

Figure 3

A: The FI value of plasma FITC-Albumin (5 mg/kg b.w., via i.n. instillation) in the ALI induced i.n. by LPS (0.5 mg/kg b.w.). B: Similar fold changes were found between FITC-Dextran (10 mg/kg b.w., via i.n. instillation) and EB (20 mg/kg b.w., via i.v. instillation) in the 6 h and 24 h LPS (4 mg/kg b.w., via i.n. instillation) groups compared to the control groups. C: Lung inflammatory lesions and thickened alveolar septa observed in ALI induced by LPS i.p. (15 mg/kg b.w.) (200X magnification). D: The concentration of plasma FITC-Dextran is significantly increased in the LPS i.p. group compared to the control group, with 10 mg of FITC-Dextran/kg b.w. via i.n. instillation (n = 3, *P<0.05, **P<0.01).