Table 1.
Characteristics associated with Mycoplasma genitalium infection among 303 HIV-1–positive women.
| Characteristic | M. genitalium negative (n = 251) | M. genitalium positive | |||
|---|---|---|---|---|---|
| Low burdena (n = 26) | P for low burdenb | High burdenc (n = 26) | P for high burdenb | ||
| Demographic and behavioral characteristics | |||||
| Age <28 years | 100 (40) | 13 (50) | .40 | 20 (77) | .001 |
| Zero sex partners in the past week | 88 (35) | 6 (23) | .28 | 2 (8) | .004 |
| Condom used in the past week | 66 (26) | 13 (50) | .02 | 12 (46) | .04 |
| Last sexual intercourse ≤7 days ago | 162 (65) | 20 (77) | .28 | 24 (92) | .004 |
| Hormonal contraceptive use (current) | 78 (33) | 6 (26) | .64 | 9 (38) | .65 |
| Cervical pathogens | |||||
| Chlamydia trachomatis | 14 (5) | 2 (8) | .65 | 5 (19) | .02 |
| Neisseria gonorrhoeae | 25 (10) | 3 (11) | .74 | 2 (8) | 1.0 |
| Clinical characteristics | |||||
| Abnormal cervical exudatesd | 67 (27) | 8 (31) | .67 | 15 (58) | .001 |
| Elevated cervical PMN count (≥30/HPF) | 68 (28) | 7 (27) | .95 | 10 (39) | .24 |
| Easily induced cervical bleeding | 43 (17) | 3 (12) | .59 | 6 (23) | .43 |
| HIV disease | |||||
| Cervical shedding of HIV-1 DNA | 125 (50) | 12 (46) | .84 | 18 (69) | .06 |
| CD4 cell count, median (range), cells/μL | 427 (29–1402) | 464 (58–934) | .79e | 402 (29–1343) | .95e |
Note. Data are no. (%) of participants, unless otherwise indicated. HPF, high-power field; PMN, polymorphonuclear leukocyte.
a
M. genitalium organism burden <3195 genomes/mL.
b
Fisher's exact test for comparison with M. genitalium–negative women, unless otherwise indicated.
c
M. genitalium organism burden ≥3195 genomes/mL.
d
Abnormal cervical discharge (cloudy/white, yellow/green, brown, or bloody exudates)
e
Wilcoxon rank sum test for comparison with M. genitalium–negative women.