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A, total and activated HER3 expression in HNSCC cell lines. Western blot was used to determine the expression of HER3 and pHER3 expression in 12 HNSCC cell lines. B, MM-121 alone inhibits HER3 and AKT activation in vitro. HNSCC cell lines SCC47 and Tu212 were treated with escalating doses of MM-121 as indicated for 12 and 24 hours. Cell lysates were immunoblotted to detect pHER3 (Tyr1289), pAKT (Ser473), total HER3 and AKT. Experiments were repeated three times.
