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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: DNA Repair (Amst). 2014 May 22;19:114–129. doi: 10.1016/j.dnarep.2014.03.020

Table 2.

Exogenous and endogenous factors producing Top2 cleavage complexes and relevant to TDP2.

Endogenous DNA lesions Notes Refs. [182]
Abasic sites Apurinic and apyrimidinic sites; BER* [183–186]
Processed abasic sites BER intermediates [187]
8-oxoguanine/8-oxoadenine Free radicals; weak topoisomerase II poison [185]
O6-methylguanine Free radicals; weak topoisomerase II poison [185]
Deoxyuracil Cytosine deamination [188]
Base mismatches DNA replication [188,189]
Ribonucleotides DNA replication [190,191]
1,N6-ethenodeoxyadenine Lipid peroxidation; industrial chemicals [185,186]
1,N2-ethenodeoxyguanosine Lipid peroxidation; industrial chemicals [186]
3,N4-ethenodeoxycytidine Lipid peroxidation; industrial chemicals [186]
3,N4-ethenodeoxycytidine Lipid peroxidation; industrial chemicals [186]
M1dG Lipid peroxidation; industrial chemicals [186]
Single-stranded DNA breaks Free radicals; cellular processes [192,193]
Exogenous DNA lesions
UV lesions Cyclobutane dimers [194]
Cytosine arabinoside Cytarabine-induced DNA lesions [195]
Ethenobase adducts Chloracetaldehyde treatment of cells [186]
benzo[a]pyrene 7,8-diol 9,10-epoxide deoxyadenosine Intercalated carcinogenic adducts [196]
*

BER: base excision repair.