. Author manuscript; available in PMC: 2015 Jul 1.

Published in final edited form as: DNA Repair (Amst). 2014 May 22;19:114–129. doi: 10.1016/j.dnarep.2014.03.020

Table 3.

Comparison of TDP1 and TDP2.

	TDP1	TDP2
Family	Phospholipase D (PLD)	Mg²⁺/Mn²⁺-dependent phosphodiesterases (MDP)
Substrates	DNA-phosphotyrosines (Top1) 3′-phosphoglycolates 3′-nucleosides	DNA-phosphotyrosines (Top2, Top3?) RNA-phosphotyrosine (VPg unlinkase)
Polarity	3′ ≫ 5′ [45,68]	5′ ≫ 3′ [134]
Catalytic mechanism	Covalent intermediate [73]	Two-metal catalysis [134]
Amino acids	608 residues	362 residues
Molecular weight	68 kDa	41 kDa
Genomic location	14q32.11	6p22.3-p22.1
Associated disease	SCAN1 [79]	Reading disability [197–199] Parkinson disease [200–202]
Knockout mice	Yes [51,203]	Yes [132]
Crystal structure with substrate	Yes [75]	Yes [137]