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. 2014 Jun 27;17(2):136–142. doi: 10.4048/jbc.2014.17.2.136

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© 2014 Korean Breast Cancer Society. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Percent of changes in derived fatty acid indices between normal-appearing and infiltrating ductal carcinoma (IDC) explants induced by CAY10566 (1.0 µM). Explants were incubated with CAY10566 (1.0 µM) for 48 hours. Lipid extracts were prepared and analyzed by gas liquid chromatography for a comprehensive fatty acid profile. Elongase activity index, 18:0/16:0; stearoyl-CoA desaturase 1 (SCD1) activity index, 18:1n-9/18:0; Δ6D activity index, 20:4n 6/18:2n 6. Data are means±SD of three independent determinations, n=12. p, paired t-test.

Δ6D=Δ6 fatty acid desaturase; 16:0=palmitic acid; 18:0=stearic acid; 18:1n-9=oleic acid; 18:2n-6=linoleic acid; 20:4n-6=arachidonic acid.