Table 1.

NTPDase5 profile expression in tumor cell lines.

Author; year	Tumor cell line	Control group	Methods	NTPDase5 expression	mt-PCPH expression
Beckenkamp et al., 2014 [14]	Cervical cancer cell lines SiHa, HeLa, and C33A	Normal immortalized keratinocytes (HaCaT cells)	RT-PCR	Expressed in all cell lines with higher levels in SiHa cells than HeLa, C33A, and HaCaT cells	Not described
Zadran et al., 2012 [15]	Human brain tumor cell lines U87 and U87vIII	Not described	WB	Expressed in U87 and at higher levels in U87vIII	Not described
Villar et al., 2007 [16]	Human prostate tumor cells lines LNCaP, C42, and PC3	Nonneoplastic human prostatic epithelial cells (RWPE-1)	RT-PCR and WB	Not detected in RWPE-1 but it was highly detected in LNCaP and in both C42 and PC3 was expressed at lower levels	Not described
Regadera et al., 2006 [17]	Testicular germ cell tumors NCCIT (mutant Tp53) and NT2/D1 (wild-type Tp53)	Not described	WB	Both cell lines expressed several NTPDase5-immunorelated polypeptides (ranged 20–90 KDa)	Low molecular-size polypeptides were less abundant in NT2/D1 than NCCIT cells
Blánquez et al., 2004 [18]	Human benign and malignant neoplastic breast samples	Normal human breast tissue samples	WB	Both normal tissue and benign and malignant breast tumors samples showed the expression of the NTPDase5 protein	Only the more aggressive breast tumor samples expressed the mt-PCPH
Blánquez et al., 2002 [19]	Cell lines cultured from explants of laryngeal tumors (SCC) at stages II, III, and IV	Primary laryngeal epithelial cells (LECs) from the normal margin of surgical specimens	WB	Expression related directly to the evolution of the three grades of laryngeal dysplasia, characterized by increments of cell proliferation in parallel with changes in epithelial differentiation	LECs expressed more mt-PCPH than normal NTPDase5 and SCCs presented a loss in the mt-NTPDase5
Rouzaut et al., 2001 [12]	20 mammary tumor derived cell lines	Not described	WB	Detectable in 8 of the 20 cells lines	The mt-PCPH, after prolonged exposures, was detectable in all but two cell lines
Rouzaut et al., 2001 [12]	18 tumor cell lines derived from the central or peripheral nervous system	Not described	WB	Absent in 13 cell lines and barely detectable in 4 cell lines	Expressed in 13 cell lines
Rouzaut et al., 2001 [12]	6 colon tumor cell lines	Not described	WB	Expressed highly in all six cell lines	Expressed in 4 cell lines
Rouzaut et al., 2001 [12]	5 lung tumor cell lines	Not described	WB	Detectable at low levels in all five cell lines	Detectable at low levels in 4 cell lines
Rouzaut et al., 2001 [12]	1 pancreas tumor cell line	Not described	WB	Highly expressed	Detectable at low levels

Legend: U87vII: U87 glioblastoma cells transduced to express the epidermal growth factor receptor vIII; WB: Western blot.