Table 2.
NTPDase5/mt-PCPH profile expression in clinical samples.
| Author; year |
Tissue study | Methods | Sampling size | Control group | NTPDase5 expression | mt-PCPH expression |
|---|---|---|---|---|---|---|
| Zadran et al., 2012 [15] | Primary glioblastoma multiforme (GBMs) | Tissue microarrays, IHC, and WB | 140 patients | Adjacent normal brain | Elevated levels were observed in GBM cores when compared to adjacent normal tissues | Not described |
| Mikula et al., 2010 [20] | Adenocarcinomas and colonic adenomas | Mass spectrometry and qRT-PCR | 5 adenocarcinomas; 12 colonic adenomas; 4 normal mucosas | Normal mucosa | Continuously downregulated in a progression from normal mucosa to adenocarcinoma | Not described |
| Villar et al., 2007 [16] | Prostate normal, hyperplasic, and tumor cells | IHC | 63 patients | Normal human prostate | Not detected in normal prostate, detected slightly in HPB, and elevated in PIN and prostate carcinoma (samples with a Gleason score less than 7 present lower levels) | Not described |
| Regadera et al., 2006 [17] | Testicular tumors | IHC | 54 patients | Normal testicular tissue | Increased expression in testicular tumors relative to normal tissue; present in well-differentiated squamous epithelia and lost in dedifferentiated squamous cells | Not described |
| Blánquez et al., 2002 [19] | Laryngeal mild, moderate, and severe stages dysplastic lesions | IHC | 59 patients | Normal laryngeal mucosa | Expressed at lower levels in severe than in mild dysplastic cases and at much lower levels than in the normal tissue | Not described |
| Blánquez et al., 2004 [18] | Human breast tumors | IHC and WB | 54 patients | Normal human breast samples | Undetectable in normal and benign samples and increase in carcinoma in situ and more strongly in invasive ductal and lobular carcinoma | Absent in benign human breast and low molecular weight polypeptides in ductal and lobular carcinoma |
| Solanas et al., 2002 [13] | Rat mammary benign and malignant tumors induced | IHC and WB | 35 malignant tumors; 19 benign tumors | Normal rat mammary gland | Tumor samples showed higher levels and were more expressed in the malignant tumors | Tumor samples showed decrease in the mt-NTPDase5 expression when compared with the normal tissue |
Legend: HPB: hyperplasia prostate benign; PIN: prostatic intraepithelial neoplasia; IHC: immunohistochemistry; WB: Western blot.