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(a) Invasive and signet ring celled tumor infiltration on the dermis between the collagen fibers (HEX200). (b) In the paratrabecular area between the bone trabeculas, fibrosis and signet ring celled tumor are being observed (HEX100). (c) Signet ring cell-like tumor cells with large hyperchromatic nucleus in the stomach mucosa (HEX200). (d) HER-2-neu positiveness determined by the FISH method in the nucleus.
