Table 3.
Predictive value of conventional US features and ARFI in 173 thyroid lesions.
| BN (n) |
CA (n) |
Sensitivity (%) |
Specificity (%) |
PPV (%) |
NPV (%) |
Accuracy (%) |
Az (95% CI) |
|
|---|---|---|---|---|---|---|---|---|
| US features | ||||||||
| Hypoechoic (including markedly hypoechoic) |
94.8 (91/96) |
27.3 (21/77) |
61.9 (91/147) |
80.8 (21/26) |
64.7 (112/173) |
0.610∗ (0.524, 0.696) |
||
| Yes | 56 | 91 | ||||||
| No | 21 | 5 | ||||||
| Spot microcalcification | 55.2 (53/96) |
71.4 (55/77) |
70.7 (53/75) |
56.1 (55/98) |
62.4 (108/173) |
0.633∗ (0.550, 0.716) |
||
| Yes | 22 | 53 | ||||||
| No | 55 | 43 | ||||||
| Shape (taller than wide) | 54.2 (52/96) |
83.1 (64/77) |
80 (52/65) |
59.3 (64/108) |
67.1 (116/173) |
0.686 (0.607, 0.766) |
||
| Yes | 13 | 52 | ||||||
| No | 64 | 44 | ||||||
| Halo sign | 99.0 (95/96) |
9.1 (7/77) |
57.6 (95/165) |
87.5 (7/8) |
59.0 (102/173) |
0.540∗ (0.453, 0.627) |
||
| Yes | 7 | 1 | ||||||
| No | 70 | 95 | ||||||
| Type III vascularity | 17.7 (17/96) |
88.3 (68/77) |
65.4 (17/26) |
46.2 (68/147) |
49.1 (85/173) |
0.455∗ (0.368, 0.542) |
||
| Yes | 9 | 17 | ||||||
| No | 68 | 79 | ||||||
| ARFI features | ||||||||
| VTI Elastography score > 4 |
61.4 (59/96) |
88.3 (68/77) |
86.8 (59/68) |
64.8 (68/105) |
73.4 (127173) |
0.746 (0.672, 0.850) |
||
| Yes | 9 | 59 | ||||||
| No | 68 | 37 | ||||||
| VTQ SWV > 3.10 m/s |
56.2 (54/96) |
79.2 (61/77) |
77.1 (54/70) |
59.2 (61/103) |
66.5 (115/173) |
0.702 (0.625, 0.780) |
||
| Yes | 16 | 54 | ||||||
| No | 61 | 42 |
Caption: BN, benign; CA, carcinoma; US, ultrasound; PPV, positive predictive value; NPV, negative predictive value.
*In comparison with “VTI elastography score > 4”, P < 0.05.