Table 2.
Protein antigens, their cellular source, and function.
| Cell | Protein | Function |
|---|---|---|
| Neuron | Neurofilament (NF) Triplet∗ | Neuronal intermediate filaments (IF) |
| NF-L (light; NF-68) | Mechanical stability of soma, dendrites, and axon | |
| NF-M (medium; NF-160) | Mechanical stability of soma, dendrites, and axon | |
| NF-H (heavy; NF-200) | Together with NF-L and NF-M, mechanical stability of the axon | |
|
| ||
| Astrocyte | Glial fibrillary acidic protein (GFAP) | IF of mature astrocytes biomarker of reactive gliosis |
| Vimentin | IF transiently expressed during development | |
|
| ||
| Myelinating cells | Myelin basic protein (MBP) | Compaction protein of myelin in CNS and PNS |
| Oligodendroglia | Myelin oligodendrocyte protein (MOG) | CNS myelin |
| Schwann Cell | Peripheral myelin protein-22 (PMP-22) | PNS myelin |
*Individual proteins differ in their immunogenicity.