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. Author manuscript; available in PMC: 2014 Sep 20.
Published in final edited form as: N Engl J Med. 2014 Mar 20;370(12):1121–1130. doi: 10.1056/NEJMoa1309220

Table 3. Respiratory and Other Disorders in the Previous 12 Months, as Documented in the Parent Questionnaire.

Respiratory Disorder Conventional Ventilation (N = 150) HFOV (N = 154) Adjusted Odds Ratio (95% CI)* P Value
Wheezing — no. (%) 22 (15) 23 (15) 1.01 (0.53–1.90) 0.98
Frequency of wheezing — no./total no. (%) 0.76
 Daily 1/22 (5) 5/22 (23)
 Weekly 1/22 (5) 2/22 (9)
 Monthly 4/22 (18) 4/22 (18)
 Less than monthly 16/22 (73) 11/22 (50)
Medication for chest problems — no./total no. (%)§
 Antibiotic agent 22/150 (15) 18/154 (12) 0.69 (0.34–1.43) 0.32
 Other medicine 24/150 (16) 23/152 (15) 0.94 (0.50–1.77) 0.85
Hospital admission — no./total no. (%) 15/150 (10) 18/152 (12) 0.95 (0.45–1.99) 0.89
 Chest problem — no.§ 4 0
 Surgery — no. 8 13
 Other — no. 8 5
Cerebral palsy — no. 13 18 0.38
*

The odds ratio was adjusted for birth weight, gestational age, and whether surfactant had been administered.

Data were missing for one child in the HFOV group.

Analyses were based on yes versus no responses.

§

Chest problems were defined as respiratory infection and asthma.

Patients may have been admitted to the hospital for multiple reasons.

The analysis assumed that participants who did not respond did not have the particular health problem. Estimates were unadjusted, owing to small numbers.