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. Author manuscript; available in PMC: 2015 Jul 2.
Published in final edited form as: Neuron. 2014 Jun 12;83(1):93–103. doi: 10.1016/j.neuron.2014.05.020

Figure 2. Linx is required for internal capsule formation.

Figure 2

Coronal sections of E18.5 brains. Immunostaining with anti-Neurofilament (A) and anti-L1 (B) in control (wild-type in A and Linx+/tEGFP in B) and LinxtEGFP/tEGFP mice, and tracing of axon tracts that connect the neocortex and thalamus in Linx+/tEGFP (control) and LinxtEGFP/tEGFP mice with DiI crystals inserted into the thalamus (C) or somatosensory cortex (D). Sections were counterstained with Hoechst 33258 in C and D. Arrows, misrouted thalamocortical projections (A and C) and remnants of the descending component of the internal capsule (B). Bars, 1 mm. These results are representative of at least eight (A) and four independent experiments (B-D). See also Figure S2.