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. 2014 Jul 10;4:5651. doi: 10.1038/srep05651

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(a) Cells were treated with 50 μM andrographolide for the indicated time periods. The extent of SHP-1 phosphorylation was then determined by immunoblotting. Compiled results are shown at the bottom of the chart. Each column represents the mean ± S.E.M. of four independent experiments. Cells were pretreated with vehicle or 10 μM SSG for 30 min followed by the treatment with 50 μM andrographolide for another 10 min. The enzyme activity of SHP-1 (b) and PP2A (c) were then determined. Compiled results are shown at the bottom of each chart. Each column represents the mean ± S.E.M. of at least four independent experiments. The full-length blot is presented in Supplementary Figure 5. (*, P < 0.05, and **, P < 0.01, compared with the control group; and ^#, P < 0.05, compared with the group treated with andrographolide alone). IP: immunoprecipitation. IB: immunoblotting.